Peptic ulcer disease
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Peptic ulcer disease

Peptic ulcer disease is a chronic relapsing sickness. The main feature of peptic ulcer disease is the formation of defects (ulcers) in the wall of the stomach or duodenum.

Peptic ulcer disease are much more common than gastric ulcers. The prevalence of duodenal ulcer localization is typical for most young people and especially for men. Most susceptible to peptic ulcer disease is people concerned with the mental stress, especially when combined with irregular meals (for example, drivers of vehicles).

Occurrence of the peptic ulcer disease has many factors

In the occurrence of the peptic ulcer disease are many factors, including violations of the regime and the nature of power (systematic use of acute and roughage, hasty eating and eating dry rations, big breaks between meals), smoking, alcohol abuse, strong coffee, psycho-emotional overload (insufficient rest and sleep, long working hours, stress), physical stress. Important is hereditary and constitutional factors. Trigger the development of peptic ulcer disease can prolonged use of drugs that adversely affect the mucous membrane of the stomach and duodenum. It is believed that an important role in the development of peptic ulcer disease and recurrent course is Helicobacter pylori, parasite in the gastric mucosa and increases its sensitivity to the effects of hydrochloric acid of gastric juice.

At the heart of peptic ulcer disease is an imbalance between the aggressive properties of gastric contents and defensive capabilities of the gastric mucosa and duodenum. Causes amplification of the acid-peptic aggression may be increased secretion of hydrochloric acid and dysmotility of the gastrointestinal tract, leading to prolonged retention of acid content in the outlet of the stomach, too fast of it in the bulb of the duodenum, bile reflux duodenogastral. The weakening of the protective properties of the mucous membrane may occur with a decrease in gastric mucus production and deterioration in its quality staff, the oppression of making hydrocarbons that make up the gastric and pancreatic juice, violating the regeneration of epithelial cells of the mucous membrane of stomach and duodenal ulcers, reducing its content of prostaglandins, reducing regional blood flow.