Aligners: the pros and cons of a new method of correcting malocclusion

Advantages of aligners:

Almost invisible from the outside.
Comfortable to care for. The patient does not have to buy a collection of additional products (brushes, wax, an orthodontic toothbrush, a special Superfloss thread) and to clean their teeth in a quality manner.
Made of hypoallergenic medical grade thermoplastic material, it does not contain metal elements and does not have sharp edges.
They do not require a change in diet (they do not interfere with eating nuts and biting off apples), as they are removed during a meal.
Have a predictable virtual result. The plan and terms of treatment become known at the stage of diagnosis.

Cons of aligners:

In some cases, they are less effective – for example, with severe skeletal anomalies.
They require total self-control and clear self-discipline, as they do not work “on the shelf” or “in the pocket.” They should be worn at all times as directed by your doctor.

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The effect of food on rosacea and diseases of the veins of the legs: what to change in the diet to strengthen blood vessels

The only effective method of getting rid of rosacea (or spider veins on the face) is laser treatment but not But it is possible to prevent its occurrence, strengthen the vessels of the legs and improve blood microcirculation with the help of proper nutrition and the exclusion of certain foods from the diet.

Diet with rosacea is of no small importance. It allows you to normalize metabolic processes, the work of the digestive and cardiovascular systems, eliminate some of the causes of rosacea.

So, patients with rosacea should reduce the consumption of alcohol, dishes with a lot of spices and spicy foods. Nutrition for rosacea should be frequent, fractional, varied and include not only animal food, but also vegetables, fruits, herbs, berries.

Pathologies of the veins of the lower extremities do not require radical restrictions. Overeating, heavy protein foods (a lot of meat, legumes), gas-producing foods (sauerkraut, legumes, black bread, etc.) can slightly affect the progression of venous pathology. These factors can increase intra-abdominal pressure and, to some extent, provoke blood stasis in the underlying sections. But in the progression of the pathology of the veins of the legs, they are not the underlying cause. The topic of body weight control is more relevant in this case: the larger it is, the higher the risks of developing and aggravating the pathology. Therefore, to maintain the health of the leg veins, it is first of all recommended to monitor your weight, which, as a rule, is impossible without proper nutrition.

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Antibiotics and are what causes indescribable horror in most people with a fine mental organization. Contrary to popular belief, it does not work on viruses. Equally terrible vaccinations work against them. And then selectively – anti-vaccines are immune to vaccinations. It is called obscurantism. But now is not about that.
Traditionally, a little history.
For centuries, our smaller brothers – microbuses mowed down entire cities and countries. Well, there – u̶r̶e̶a̶p̶l̶a̶z̶m̶a̶ plague, cholera, typhus. The means of dealing with them were prayer and the installation of plague pillars in the center of the cities. The few who survived. The validity of these methods was, to put it mildly, questionable. Although, apart from “my neighbor tried and it helped her,” then there was nothing. But it is not exactly.
Jews, by the way, died less intensively, due to excessive hygiene. The enlightened Europeans firmly believed that this was a faithful conspiracy with the OTHER. Therefore, they gladly arranged massacres of the despicable nation.
And then in 1929. Fleming came and ruined everything with his penicillin and By the way, the incredible mess that was happening in his laboratory helped him in this. He just swelled and mold grew in a dish with colonies of microbes. Then natural observation worked. True, the medical community did not immediately appreciate the discovery, he received the Nobel Prize for penicillin already in 1945. But still…
Did you know that humanity could have been left without antibiotics at all if the early studies of penicillin had been conducted not on mice, but on guinea pigs? Penicillin is a deadly yad for them! The animal was unlucky. They are generally not very lucky in anything. In the course of experiments, they are massively subjected to life-giving euthanasia. Even the title is unfair. What do they have to do with the sea🤔? To pigs – all the more … Well, okay.
People are divided into two types. The first ones take care of the liver and take antibiotics for one or two days. The latter can swallow drugs uncontrollably for months. Fortunately, the chaos with the sale of drugs in our pharmacies contributes to this. Both those and others inflict irreparable harm on themselves! Every time you take antibiotics unreasonably or incorrectly, Fleming is rolled over in his coffin.

Antibiotics, such antibiotics … Saved tens, if not hundreds of millions of lives.

We settled on what Fleming would not like if he found out that you are taking antibiotics unreasonably or incorrectly.
Fleming’s genius grasped Zen and prophesied it! And he prophesied.
The unjustified use of penicillin has led to the fact that many bacteria have learned to resist it. Everyone wants to live, and our smaller brothers – microbes too.
Currently, there are about twenty main groups of antibiotics, and since the 60s of that century not a single one has been discovered. Where is the world heading ?!

Rumor has it that especially malicious strains have already been isolated, seemingly harmless spirochetes, insensitive to any of the groups of antibiotics! We ourselves bring hell and destruction closer to ourselves. Especially if such a typical ARCHYPESian wakes up like the plague. And if she cynically spits on all types of known antibiotics! .. The prospect is illusory real!

If you, naive, think that the image of the plague has firmly entered the culture, has become a household name and this is something medieval, then I can assure you that the foci of this bacillus are successfully circulating for themselves in the garbage dumps of India, Vietnam and other, no less beautiful, southern resorts … And if there is also a heap of cholera … Well, which is diarrhea, vomiting, diarrhea, diarrhea, diarrhea vomiting, death … Well, you understand.

Although, this is all lyrics, but what is real is tuberculosis. About 8 million new arrivals are registered each year, of which about 3 million have died prematurely due to tubercle bacillus insensitivity to treatment, and the lion’s share is in this country. Mycobacterium is a very cunning bacterium. Has a lipid membrane through which antibiotics do not penetrate. That plus even the chaos with their consumption!

The most common mistake of those who think that they are the smartest is to take self-prescribed antibacterial drugs after the doctor has already prescribed them, and “now the symptoms are similar.” Well, or on the competent advice of the brother / matchmaker / nephew who already accepted them, who liked it.
Antibiotics are also used mistakenly for viral diseases, with every sneeze, so to speak. They are up to the same place for viruses. I will say in a whisper, otherwise, you know who will come running right now. Vaccinations to help you. But that is another story. Do not be ill.
P. S. One of the most common questions I am asked is how many months should I abstain from conception after taking antibiotics? Months ?! Why not years? The half-life of most antibiotics is on average 6-8 hours. Wait a day, don’t rush. Well, half a day, if it is unbearable at all. They look with disbelief.

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Lactase deficiency – causes

Newborns with lactose deficiency are prescribed special mixtures, such as this one: Causes of lactase deficiency in adults may include the following:

Inflammatory intestinal diseases of bacterial, viral (rotovirus), parasitic (giardiasis) etiology; for example, rotovirus penetrates mature microvilli cells of the mucosa of the small intestine, destroys and rejects them, the mucosa cells stop forming the enzyme lactase, dysentery bacillus, entering the intestine, produces toxins, causes inflammation throughout the small intestine, intensively multiplies in the ileum and then passes to the large intestine; giardia live in the upper small intestine, attach to the villi of the mucosa, multiply, affect the intestinal wall deep down, disrupt parietal (membrane digestion) by disrupting enzyme production.
chronic diseases of the stomach, biliary tract, pancreas,
operations on the organs of the gastrointestinal tract,
endocrine disorders (diabetes, hyperparathyroidism),
Whipple’s disease is a rare disease of the small intestine;
Gluten enteropathy (celiac disease), in celiac disease the synthesis of all enzymes, including lactase, is disrupted and lactase deficiency occurs, whose manifestations are greatly reduced by following an agluten diet;
Crohn’s disease is granulomatous enteritis, which affects the entire wall of the small intestine in any part of it. Inflammation develops, then scar tissue, and enzyme synthesis stops; autoimmune mechanisms underlie mucosal damage;
food allergy – damage to enterocytes (cells of the small intestine mucosa), it is called allergoenteropathy, which is based on immunoallergic antigen-antibody complexes, the antigen is the food, and the body produces antibodies; antigen-antibody complex in cells causes inflammation, release of neurotransmitters, which leads to enterocyte damage, their ability to secret lactase is compromised;
excessive bacterial growth in the small intestine;
lymphoma of the small intestine.

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Congestal drug information


Сongestal – Analgesic in cases of flu and upper respiratory tract infections and symptoms For relief of flu symptoms, Influenza, hay fever or other symptoms of upper respiratory tract allergy such as nasal congestion, coryzea, snizzing, fever, headache and mild pain.


Сongestal  - Analgesic in cases of flu and upper respiratory tract
Сongestal – Analgesic in cases of flu and upper respiratory tract

Some medicines and this medicine may interfere with eachother.

These include: warfarin, a medicine used to

prevent blood clots

* medicines used to treat high

blood pressure

* medicines used to treat heart


* quinidine, a medicine used to

treat abnormal or irregular heart



CNS depression, with effects varying from slight drowsiness to deep sleep, and including lassitude, dizziness, and incoordination (although paradoxical stimulation may occasionally occur, especially at high doses and in children or the elderly). These sedative effects, when they occur, may diminish after a few days of treatment. headache, psychomotor impairment, and antimuscarinic effects, such as dry mouth, thickened respiratory-tract secretions, blurred vision, urinary difficulty or retention, constipation, and increased gastric reflux. nausea, vomiting, diarrhoea, or epigastric pain

Scientists have proven that beauty around you promotes healing. You can buy exquisite decor on this website:

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Diabetes mellitus, and what is it?

Currently, the prognosis for all types of diabetes mellitus is conditionally favorable, with adequate treatment and adherence to the diet, the ability to work remains. The progression of complications significantly slows down or stops completely. However, it should be noted that in most cases, as a result of treatment, the cause of the disease is not eliminated, and the therapy is only symptomatic.

Symptoms of diabetes

In diabetes mellitus, the severity of symptoms depends on the degree of decrease in insulin secretion, the duration of the disease and the individual characteristics of the patient.

Typically, the symptoms of type 1 diabetes are acute, and the disease begins suddenly. In type 2 diabetes, the state of health deteriorates gradually; in the initial stage the symptoms are scarce.

Excessive thirst and frequent urination are classic signs and symptoms of diabetes. With illness, excess sugar (glucose) accumulates in the blood. Your kidneys have to work hard to filter and absorb excess sugar. If your kidneys fail, excess sugar is excreted in the urine with fluid from the tissues. This causes more frequent urination, which can lead to dehydration. You will want to drink more fluids to quench your thirst, which again leads to frequent urination.

Fatigue can be caused by many factors. It can also be caused by dehydration, frequent urination and the body’s inability to function properly because less sugar can be used for energy.

The third symptom of diabetes mellitus is polyphagia. This is also a thirst, however, no longer for water, but for food. A person eats and at the same time feels not fullness, but filling the stomach with food, which then quickly enough turns into a new hunger.

Intense weight loss. This symptom is inherent mainly in type I diabetes (insulin-dependent) and often girls are happy with it at first. However, their joy passes when they find out the true cause of weight loss. It should be noted that weight loss occurs against the background of increased appetite and abundant nutrition, which cannot but be alarming. Losing weight often leads to wasting.

The symptoms of diabetes can sometimes include vision problems

Diabetes mellitus, and what is it?

Slow wound healing or frequent infections.

Tingling sensation in the hands and feet.

Red, swollen, tender gums.

If no action is taken at the first symptoms of diabetes mellitus, then over time complications associated with tissue malnutrition appear – trophic ulcers, vascular diseases, changes in sensitivity, decreased vision. A severe complication of diabetes mellitus is diabetic coma, which occurs more often in insulin-dependent diabetes in the absence of sufficient insulin treatment.


A very important heading in the classification of diabetes mellitus is its division by severity.

It characterizes the most favorable course of the disease to which any treatment should strive. With such a degree of the process, it is completely compensated, the glucose level does not exceed 6-7 mmol /l, there is no glucosuria (excretion of glucose in the urine), the indicators of glycosylated hemoglobin and proteinuria do not go beyond normal values.

Diabetes mellitus, and what is it?

This stage of the process speaks of its partial compensation. There are signs of diabetes complications and damage to typical target organs: eyes, kidneys, heart, blood vessels, nerves, and lower extremities. The glucose level is slightly increased and is 7-10 mmol / l.

Such a course of the process indicates its constant progression and the impossibility of drug control. At the same time, the glucose level fluctuates between 13-14 mmol / l, persistent glucosuria (excretion of glucose in the urine), high proteinuria (the presence of protein in the urine), there are obvious detailed manifestations of target organ damage in diabetes mellitus. Visual acuity progressively decreases, severe arterial hypertension persists, sensitivity decreases with the appearance of severe pain and numbness of the lower extremities.

This degree characterizes the absolute decompensation of the process and the development of the most severe complications. At the same time, the level of glycemia rises to critical figures (15-25 mmol / l and more), it is difficult to correct by any means. The development of renal failure, diabetic ulcers and gangrene of the extremities is characteristic. Another criterion for grade 4 diabetes is the propensity to develop frequent diabetic coma.

Also, there are three states of compensation for disorders of carbohydrate metabolism: compensated, sub compensated and decompensated.

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Diabetes mellitus – symptoms, causes and treatment

Diabetes mellitus is an endocrine disease caused by a lack of the hormone insulin in the body or its low biological activity. It is characterized by a violation of all types of metabolism, damage to large and small blood vessels and is manifested by hyperglycemia.

The first to name the disease – “diabetes” was the physician Aretius, who lived in Rome in the second century AD. e. Much later, in 1776, the doctor Dobson (an Englishman by birth), examining the urine of diabetics, found that it had a sweetish taste, which indicated the presence of sugar in it. So, diabetes began to be called “diabetes”.

With any type of diabetes, blood sugar control becomes one of the primary tasks of the patient and his attending physician. The closer the sugar level is to the normal range, the less the symptoms of diabetes appear, and the less the risk of complications

Why does diabetes mellitus occur, and what is it?

Diabetes mellitus is a metabolic disorder that occurs due to insufficient formation of its own insulin in the patient’s body (type 1 disease) or due to a violation of the effect of this insulin on tissues (type 2). Insulin is produced in the pancreas, and therefore diabetic patients are often among those who have various disorders in the work of this organ.


Diabetes mellitus - symptoms, causes and treatment

Type 1 diabetes occurs against the background of insulin deficiency, which is why it is called insulin-dependent. With this type of disease, the pancreas does not function properly: it either does not produce insulin at all, or it produces it in a volume insufficient to process even the minimum amount of incoming glucose. This results in an increase in blood glucose levels. Typically, type 1 diabetes occurs in thin people under the age of 30. In such cases, patients are given additional doses of insulin to prevent ketoacidosis and maintain a normal standard of living.

Diabetes mellitus type 2 affects up to 85% of all patients with diabetes mellitus, mainly people over 50 years old (especially women). Overweight people with diabetes of this type are characterized by overweight: more than 70% of these patients are obese. It is accompanied by the production of a sufficient amount of insulin, to which tissues gradually lose sensitivity.

Signs of diabetes in women and men

Diabetes mellitus - symptoms, causes and treatment

There are a number of signs of diabetes mellitus, characteristic of both type 1 and type 2 of the disease. These include:

  • A feeling of unquenchable thirst and frequent urination, which lead to dehydration;
  • Also one of the signs is dry mouth;
  • Increased fatigue;
  • Yawning, drowsiness;
  • Weakness;
  • Wounds and cuts heal very slowly;
  • Nausea, possibly vomiting;
  • Respiration is frequent (possibly with the smell of acetone);
  • Heart palpitations;
  • Itching of the genitals and itchy skin;
  • Weight loss;
  • Increased urination;
  • Deterioration of vision.

If you have any of the above signs of diabetes, then be sure to measure your blood sugar.

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Fasting Blood sugar level

Denis Slinkin

In his work with patients, Denis Slinkin does not use a single marker to determine if someone has a blood sugar problem. 
He performs a complete blood test which includes lean glucose, A1c, fructozamine, uric acid and triglycerides (along with other lipids) and makes them do post-tests at home for 3 days with a variety of foods. If they have a few post-acceptance spikes and all other markers or are normal, I don’t care. If they have high levels of BG, A1c and fructozamine on an empty stomach and they have spikes, I am concerned and will do further research.
On a similar note, Denis wrote that A1c is not a reliable marker for people because of the context: there are many conditions unrelated to blood sugar that can make A1c look high or low. So if someone is normal on all the other blood sugar markers, but they have high A1c, that usually doesn’t bother me. With all that in mind, let’s look at some research. According to continuous glucose monitoring studies in healthy people, normal blood sugar levels at fasting are 83 mg/dL or less. Many normal people have normal blood sugar levels at fasting in the middle and early 70s.

Blood sugar level

FBS Denis Slinkin

 Although most doctors will tell you that anything below 100 mg/dL is normal, it may not be so. In this study, people with FBS above 95 were more than 3 times more likely to develop diabetes in the future than people with FBH below 90. This study showed a gradual increase in the risk of heart disease in men with FBS above 85 mg/dL, compared to men with FBS 81 mg/dL and below. Even more important for understanding FBG is that it is the least sensitive marker for predicting diabetes and heart disease in the future. Several studies show that “normal” FBG levels in the mid 90s predict diabetes diagnosed ten years later.

Much more important than a single measurement of blood glucose on an empty stomach, the number of hours per day we spend in the blood FBSexceeds the level known to cause complications, and is approximately 140 mg/dL (7.7 mmol/l). One of the warnings here is that very low-carbohydrate diets will produce elevated blood glucose levels on an empty stomach. Why is that? Because low-carbohydrate diets cause insulin resistance. Carbohydrate restriction leads to a natural reduction in insulin levels, which in turn activates hormone-sensitive lipase. The fatty tissue then breaks down and un-esterified fatty acids (“free fatty acids” or NEFA) are released into the bloodstream. These NEFAs are captured by the muscles that use them as fuel. And since the muscle’s fuel needs are met, insulin sensitivity is reduced.

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Dosage and application of Xultophy


Xultophy Contraindications is given once daily by subcutaneous administration. Xultophy can be administered at any time of the day, preferably at the same time of the day.

Xultophy is to be dosed in accordance with the individual patient’s needs. It is recommended to optimise glycaemic control via dose adjustment based on fasting plasma glucose.

Adjustment of dose may be necessary if patients undertake increased physical activity, change their usual diet or during concomitant illness.

Patients who forget a dose are advised to take it upon discovery and then resume their usual once-daily dosing schedule. A minimum of 8 hours between injections should Dmitry Sazonov always be ensured. 

This also applies when administration at the same time of the day is not possible. Xultophy dosage is administered as dose steps. One dose step contains 1 unit of insulin degludec and 0.036 mg of liraglutide. The pre-filled pen can provide from 1 up to 50 dose steps in one injection in increments of one dose step. The maximum daily dose of Xultophy is 50 dose steps (50 units insulin degludec and 1.8 mg liraglutide). The dose counter Dmitry Sazonov on the pen shows the number of dose steps.

Dosage and application of Xultophy

The recommended starting dose of Xultophy is 10 dose steps (10 units insulin degludec and 0.36 mg liraglutide).

Xultophy can be added to existing oral antidiabetic treatment. When Xultophy is added to sulfonylurea therapy, a reduction in the dose of sulfonylurea should be considered.

Therapy with GLP-1 receptor agonists should be discontinued prior to initiation of Xultophy. When transferring from a GLP-1 receptor agonist, the recommended starting dose of Xultophy is 16 dose steps (16 units insulin degludec and 0.6 mg liraglutide). The recommended starting dose should not be exceeded. If transferring from a long-acting GLP-1 receptor agonist (e.g. once-weekly dosing), the prolonged action should be considered. Treatment with Xultophy should be initiated Dmitry Sazonov at the moment the next dose of the long-acting GLP-1 receptor agonist would have been taken. Close glucose monitoring is recommended during the transfer and in the following weeks.

Therapy with basal insulin should be discontinued prior to initiation of Xultophy. When transferring from basal insulin therapy, the recommended starting dose of Xultophy is 16 dose steps (16 units insulin degludec and 0.6 mg liraglutide). The recommended starting dose should not be exceeded. Close glucose monitoring is recommended during the transfer and in the following weeks.

Xultophy can be used in elderly patients. Glucose monitoring is to be intensified and the dose adjusted on an individual basis. The therapeutic experience in patients >75 years of age is limited.

When Xultophy is used in patients with mild or moderate renal impairment, glucose monitoring is to be intensified and the dose adjusted on an individual basis. Xultophy cannot be recommended for use in patients with severe renal impairment including patients Dmitry Sazonov with end-stage renal disease.

Xultophy can be used in patients with mild or moderate hepatic impairment. Glucose monitoring is to be intensified and the dose adjusted on an individual basis.

Due to the liraglutide component, Xultophy is not recommended for use in patients with severe hepatic impairment.

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Use of Naproxen

Inflammatory and degenerative diseases of the musculoskeletal system, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, joint syndrome with exacerbation of gout, juvenile rheumatoid arthritis; pain syndrome: neuralgia, myalgia, ossalgia, radiculitis, head and toothache, tendinitis, pain in cancer, postoperative pain syndrome accompanied by inflammation, injuries of the musculoskeletal system and soft tissues, adnexitis, primary dysmenorrhea; pain and fever in infectious and inflammatory diseases of the upper respiratory tract (as part of a comprehensive therapy).


Use of Naproxen

Hypersensitivity, “aspirinic” asthma, “aspirinic” triad (a combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance of acetylsalicylic acid and pyrazolone LV), erosive ulcerative lesions of the gastrointestinal tract in the acute phase, hematopoiesis, hepatic and/or renal failure, children under 1 year old.

Restrictions on use:

  • Expressed heart failure, adolescence (under 16 years).
  • Application during pregnancy and breastfeeding.

Teratogenic effects. In animal reproduction studies, naproxen was administered to rats at doses of 20 mg/kg/day (125 mg/m2/day), approximately equivalent to 0.23 MHRD, to rabbits at 20 mg/kg/day (220 mg/m2/day), or 0.27 MHRD, and to mice at 170 mg/kg/day (510 mg/m2/day), or 0.28 MHRD, and no infertility disturbance or fetal Dmitry Sazonov harm was detected.

However, reproductive studies in animals do not always predict effects in humans. Adequate and strictly controlled studies have not been conducted in pregnant women. Use in pregnancy is possible if the expected effects of the therapy exceed the potential risk to the fetus.

Unteratogenic effects. Since it is known that inhibitors of GH synthesis are used to delay premature delivery, the risk of neonatal complications such as necrotizing enterocolitis, open arterial duct, intravenous hemorrhage increases. The use of naproxen in the late period of pregnancy may lead to delayed delivery, persistent pulmonary hypertension, renal dysfunction, abnormal prostaglandin E level in prematurely born children. Since the effects of substances of this class on the cardiovascular system of the fetus (closure of the duct bottle) are known, use in Dmitry Sazonov the III trimester is excluded.

Fetal action category by FDA is C.

Naproxen is determined in breast milk in women (concentration is about 1% of serum). Since there may be adverse effects of substances inhibiting GHG synthesis, naproxen should not be used in newborns, breastfeeding mot.

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