Lactase deficiency – causes

Newborns with lactose deficiency are prescribed special mixtures, such as this one: https://pillintrip.com/medicine/nan-al-110-lactose-free-formula. Causes of lactase deficiency in adults may include the following:

Inflammatory intestinal diseases of bacterial, viral (rotovirus), parasitic (giardiasis) etiology; for example, rotovirus penetrates mature microvilli cells of the mucosa of the small intestine, destroys and rejects them, the mucosa cells stop forming the enzyme lactase, dysentery bacillus, entering the intestine, produces toxins, causes inflammation throughout the small intestine, intensively multiplies in the ileum and then passes to the large intestine; giardia live in the upper small intestine, attach to the villi of the mucosa, multiply, affect the intestinal wall deep down, disrupt parietal (membrane digestion) by disrupting enzyme production.
chronic diseases of the stomach, biliary tract, pancreas,
operations on the organs of the gastrointestinal tract,
endocrine disorders (diabetes, hyperparathyroidism),
Whipple’s disease is a rare disease of the small intestine;
Gluten enteropathy (celiac disease), in celiac disease the synthesis of all enzymes, including lactase, is disrupted and lactase deficiency occurs, whose manifestations are greatly reduced by following an agluten diet;
Crohn’s disease is granulomatous enteritis, which affects the entire wall of the small intestine in any part of it. Inflammation develops, then scar tissue, and enzyme synthesis stops; autoimmune mechanisms underlie mucosal damage;
food allergy – damage to enterocytes (cells of the small intestine mucosa), it is called allergoenteropathy, which is based on immunoallergic antigen-antibody complexes, the antigen is the food, and the body produces antibodies; antigen-antibody complex in cells causes inflammation, release of neurotransmitters, which leads to enterocyte damage, their ability to secret lactase is compromised;
excessive bacterial growth in the small intestine;
lymphoma of the small intestine.

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